MI300X vs Quadro P4000

CDNA 3vsPascalUpdated 36 days ago

MI300X emerges as the clear winner for prevalent AI and HPC workloads: 192 GB VRAM and 1307 TFLOPS FP16 deliver unmatched scale, justifying $2.63 per hour average over P4000's outdated 5.3 TFLOPS and 8 GB limits. Modern tasks demand its bandwidth and precision advantages.

MI300X from $1.99/hrQuadro P4000 from $0.51/hr

Specifications Compared

SpecMI300XQUADRO-P4000
TDP750W105W
VRAM192 GB8 GB
Memory TypeHBM3GDDR5
ArchitectureCDNA 3Pascal
Form FactorsOAMPCIe
InterconnectInfinity Fabric, PCIe 5.0
FP8 Performance2,614 TFLOPS
FP16 Performance1,307 TFLOPS5.3 TFLOPS
FP32 Performance163 TFLOPS5.3 TFLOPS
FP64 Performance81.7 TFLOPS
INT8 Performance2,614 TOPS
Memory Bandwidth5,300 GB/s243 GB/s

Performance Analysis

MI300X dominates compute workloads: its FP16 reaches 1307 TFLOPS and FP32 163 TFLOPS, dwarfing P4000's 5.3 TFLOPS in both. This disparity accelerates deep learning training, where FP16 tensor cores in MI300X enable 246 times faster matrix operations than P4000. Inference benefits similarly, with FP8 at 2614 TFLOPS on MI300X supporting massive models at low latency. P4000's balanced FP16 and FP32 at 5.3 TFLOPS limits it to smaller-scale tasks. Memory specs amplify differences: MI300X's 192 GB HBM3 versus 8 GB GDDR5 allows batch sizes scaled by factors of 24 for large language models, preventing out-of-memory errors in training. Bandwidth at 5300 GB/s on MI300X versus 243 GB/s on P4000 sustains high throughput, reducing bottlenecks in data loading for scientific simulations or diffusion models. Power draw reflects intent: 750W TDP for MI300X suits dense clusters, while 105W on P4000 fits edge or mobile setups.

Live Cloud Pricing

Real-time prices from 25+ providers. Updated every 60 seconds.

MI300X

ProviderGPU ModelVRAMHost SpecsRegionPriceStatusAction
RunPod
RunPod
AMD Instinct MI300X
192GB VRAM
$1.99/GPU/hr
Hot Aisle
Hot Aisle
AMD Instinct MI300X
192GB VRAM
$1.99/GPU/hr
Available
Cirrascale
Cirrascale
8×AMD Instinct MI300X
192GB VRAM
$3.08/GPU/hr
$24.64/hr total (8×)
Crusoe
Crusoe
AMD Instinct MI300X
192GB VRAM
$3.45/GPU/hr
Cirrascale
Cirrascale
8×AMD Instinct MI300X
192GB VRAM
$3.47/GPU/hr
$27.76/hr total (8×)

Quadro P4000

ProviderGPU ModelVRAMHost SpecsRegionPriceStatusAction
Paperspace
Paperspace
NVIDIA Quadro P4000
8GB VRAM
$0.51/GPU/hr
Available
Paperspace
Paperspace
2×NVIDIA Quadro P4000
8GB VRAM
$0.51/GPU/hr
$1.02/hr total (2×)
Available
Paperspace
Paperspace
2×NVIDIA Quadro P4000
8GB VRAM
$0.51/GPU/hr
$1.02/hr total (2×)
Available
Paperspace
Paperspace
NVIDIA Quadro P4000
8GB VRAM
$0.51/GPU/hr
Available
Paperspace
Paperspace
NVIDIA Quadro P4000
8GB VRAM
$0.51/GPU/hr
Available

Compare real-time pricing across 25+ providers

When to Choose the MI300X

Select MI300X for large-scale AI training and inference: its 192 GB VRAM handles models exceeding 100 billion parameters, and 1307 TFLOPS FP16 processes batches infeasible on 8 GB alternatives. HPC simulations thrive on 5300 GB/s bandwidth and Infinity Fabric interconnects. Cloud users prioritize it when $2.63 per hour average unlocks 246 times FP16 uplift over legacy options.

When to Choose the Quadro P4000

Choose Quadro P4000 for legacy CUDA applications or low-power workstations: its PCIe form factor and 105W TDP integrate easily into older systems without thermal strain. Visualization tasks like CAD rendering leverage 5.3 TFLOPS FP32 at $0.51 per hour, ideal for prototyping without high costs. It suffices for small-scale inference where 8 GB VRAM meets modest model needs.

Use Cases

LLM Training
MI300X

MI300X's 192 GB HBM3 and 1307 TFLOPS FP16 support massive parameter training with large batches. P4000's 8 GB VRAM cannot handle such scales.

LLM Inference
MI300X

2614 TFLOPS FP8 and 5300 GB/s bandwidth on MI300X enable high-throughput serving of large models. P4000's 5.3 TFLOPS limits it to tiny deployments.

Fine-tuning
MI300X

163 TFLOPS FP32 and 192 GB VRAM on MI300X accelerate efficient fine-tuning of billion-parameter models. P4000 lacks capacity for datasets over 8 GB.

Stable Diffusion
MI300X

MI300X's high FP16 performance and memory sustain high-resolution generations at scale. P4000 struggles with 243 GB/s bandwidth for iterative diffusion steps.

Scientific Computing
MI300X

Infinity Fabric and 5300 GB/s bandwidth on MI300X optimize multi-GPU simulations. P4000's Pascal limits complex floating-point workloads.

Frequently Asked Questions

What is the VRAM difference between MI300X and Quadro P4000?

MI300X provides 192 GB HBM3, enabling large model handling. Quadro P4000 offers 8 GB GDDR5, suitable only for smaller workloads.

How do FP16 performances compare?

MI300X achieves 1307 TFLOPS FP16, vastly superior for AI tasks. Quadro P4000 delivers 5.3 TFLOPS, adequate for basic compute.

What are the current cloud prices?

MI300X starts from $0.50 per hour, averaging $2.63 across nine offers. Quadro P4000 is from $0.51 per hour, averaging $0.51 across six offers.

Which has higher memory bandwidth?

MI300X reaches 5300 GB/s with HBM3, supporting high-throughput data movement. Quadro P4000 provides 243 GB/s GDDR5.

What are the TDPs?

MI300X consumes 750W for data center use. Quadro P4000 uses 105W, fitting low-power setups.

Which architecture is newer?

MI300X uses CDNA 3 from 2023 for AI optimization. Quadro P4000 employs Pascal from 2017 for professional graphics.

Which is cheaper to rent, the MI300X or the Quadro P4000?

Cloud rental prices for both the MI300X and Quadro P4000 vary by provider, configuration, and availability. This page shows live pricing from 25+ providers updated every 60 seconds. Scroll to the Live Cloud Pricing section to compare current rates.

How much VRAM does the MI300X have compared to the Quadro P4000?

The MI300X has 192 GB of HBM3 memory. The Quadro P4000 has 8 GB of GDDR5 memory.

Can I find MI300X and Quadro P4000 GPUs available to rent right now?

Yes. This page shows real-time availability across 25+ cloud GPU providers. The Live Cloud Pricing section displays only in-stock offers with current pricing.

What is the main difference between the MI300X and the Quadro P4000?

The MI300X uses the CDNA 3 architecture (2023) while the Quadro P4000 uses Pascal (2017). The MI300X delivers 246.6x the FP16 throughput and 21.8x the memory bandwidth of the Quadro P4000.