Specifications Compared
| Spec | MI250X | MI300X |
|---|---|---|
| TDP | 560W | 750W |
| VRAM | 128 GB | 192 GB |
| Memory Type | HBM2e | HBM3 |
| Architecture | CDNA 2 | CDNA 3 |
| Form Factors | OAM | OAM |
| Interconnect | Infinity Fabric | Infinity Fabric, PCIe 5.0 |
| FP16 Performance | 383 TFLOPS | 1,307 TFLOPS |
| FP32 Performance | 383 TFLOPS | 163 TFLOPS |
| FP64 Performance | 48 TFLOPS | 81.7 TFLOPS |
| Memory Bandwidth | 3,277 GB/s | 5,300 GB/s |
Performance Analysis
MI300X outperforms in low-precision formats essential for AI: 1307 TFLOPS FP16 is 3.4 times MI250X's 383 TFLOPS, accelerating neural network training and inference where FP16 reduces memory use without much accuracy loss. Its 2614 TFLOPS FP8 further optimizes inference for large language models, enabling higher throughput on quantized models.
MI250X maintains advantage in FP32 at 383 TFLOPS over MI300X's 163 TFLOPS, benefiting simulations or legacy codes demanding single-precision floating point. This delta means MI250X handles FP32-dominant tasks faster, but MI300X suits mixed-precision workflows common today.
Memory specs impact real-world scaling: MI300X's 5300 GB/s bandwidth and 192 GB VRAM support larger batch sizes in training, reducing iterations for models like LLMs, while MI250X's 3277 GB/s and 128 GB limit batches sooner, increasing overhead.
Live Cloud Pricing
Real-time prices from 25+ providers. Updated every 60 seconds.
MI250X
| Provider | GPU Model | VRAM | Host Specs | Region | Price | Status | Action | |
|---|---|---|---|---|---|---|---|---|
 Cirrascale | 4×AMD Instinct MI250X 128GB VRAM | 128GB | 256 vCPU 1024GB RAM 11882GB Storage | United States | $1.28/GPU/hr $5.12/hr total (4×) | |||
Cirrascale | 4×AMD Instinct MI250X 128GB VRAM | 128GB | 256 vCPU 1024GB RAM 11882GB Storage | United States | $1.44/GPU/hr $5.76/hr total (4×) | |||
Cirrascale | 4×AMD Instinct MI250X 128GB VRAM | 128GB | 256 vCPU 1024GB RAM 11882GB Storage | United States | $1.52/GPU/hr $6.08/hr total (4×) | |||
Cirrascale | 4×AMD Instinct MI250X 128GB VRAM | 128GB | 256 vCPU 1024GB RAM 11882GB Storage | United States | $1.60/GPU/hr $6.40/hr total (4×) |
MI300X
| Provider | GPU Model | VRAM | Host Specs | Region | Price | Status | Action | |
|---|---|---|---|---|---|---|---|---|
 RunPod | AMD Instinct MI300X 192GB VRAM | 192GB | 24 vCPU 256GB RAM | 🌍global | $1.99/GPU/hr | |||
 Hot Aisle | AMD Instinct MI300X 192GB VRAM | 192GB | 8 vCPU 224GB RAM 12288GB Storage | Michigan | $1.99/GPU/hr | Available | ||
Cirrascale | 8×AMD Instinct MI300X 192GB VRAM | 192GB | 192 vCPU 2355GB RAM 44538GB Storage | United States | $3.08/GPU/hr $24.64/hr total (8×) | |||
 Crusoe | AMD Instinct MI300X 192GB VRAM | 192GB | 0 vCPU 0GB RAM | United States | $3.45/GPU/hr | |||
Cirrascale | 8×AMD Instinct MI300X 192GB VRAM | 192GB | 192 vCPU 2355GB RAM 44538GB Storage | United States | $3.47/GPU/hr $27.76/hr total (8×) |
When to Choose the MI250X
Choose MI250X for FP32-intensive applications such as certain scientific simulations or engineering computations. Its 383 TFLOPS FP32 surpasses MI300X's 163 TFLOPS, ensuring faster execution where single-precision is required. Lower TDP of 560W versus 750W also lowers cooling and power expenses in dense deployments.
Stable average pricing at $1.46 per hour across four offers provides predictability for long-running jobs, unlike MI300X's wider variance.
When to Choose the MI300X
MI300X excels in modern AI pipelines leveraging low-precision compute. With 1307 TFLOPS FP16 and 2614 TFLOPS FP8, it processes LLM training and inference far quicker than MI250X's 383 TFLOPS FP16. Expanded 192 GB HBM3 VRAM handles massive models without fragmentation.
Higher bandwidth of 5300 GB/s supports large-batch training, and nine cloud offers starting at $0.50 per hour offer flexibility for bursty workloads.
Use Cases
MI300X's 1307 TFLOPS FP16 and 192 GB VRAM support larger models and batches than MI250X's 383 TFLOPS and 128 GB. Bandwidth of 5300 GB/s minimizes data bottlenecks during training.
2614 TFLOPS FP8 on MI300X optimizes quantized inference for high throughput. More VRAM accommodates multiple concurrent requests versus MI250X.
Higher FP16 performance of 1307 TFLOPS and 5300 GB/s bandwidth on MI300X speed up parameter updates on large models. It outperforms MI250X in memory-bound fine-tuning scenarios.
MI300X's 192 GB VRAM and 1307 TFLOPS FP16 handle high-resolution image generation without swapping. Superior bandwidth accelerates diffusion steps over MI250X.
MI250X's 383 TFLOPS FP32 exceeds MI300X's 163 TFLOPS for precision-sensitive simulations. Lower 560W TDP suits sustained HPC runs.
Frequently Asked Questions
Which GPU has more VRAM, MI250X or MI300X?▾
MI300X provides 192 GB HBM3 VRAM, exceeding MI250X's 128 GB HBM2e. This allows MI300X to load larger models for AI tasks. Bandwidth follows suit at 5300 GB/s versus 3277 GB/s.
How do FP16 performances compare between MI250X and MI300X?▾
MI300X achieves 1307 TFLOPS FP16, 3.4 times higher than MI250X's 383 TFLOPS. This boosts training and inference speeds in deep learning. MI300X adds 2614 TFLOPS FP8 for further gains.
What are the current cloud prices for these GPUs?▾
MI250X starts from $1.28 per hour, averaging $1.46 across four offers. MI300X begins at $0.50 per hour, averaging $2.63 across nine offers. Prices fluctuate based on provider and region.
Which has higher power consumption, MI250X or MI300X?▾
MI300X draws 750W TDP compared to MI250X's 560W. This reflects denser compute in CDNA 3 architecture. Users must account for cooling in multi-GPU setups.
Is MI300X better for FP32 workloads?▾
No, MI250X offers 383 TFLOPS FP32 versus MI300X's 163 TFLOPS. Choose MI250X for FP32-heavy scientific computing. MI300X prioritizes FP16 and FP8.
What interconnects do these GPUs support?▾
Both use Infinity Fabric, with MI300X adding PCIe 5.0. This enhances multi-GPU scaling in clusters. Form factor is OAM for both.
Which is cheaper to rent, the MI250X or the MI300X?▾
Cloud rental prices for both the MI250X and MI300X vary by provider, configuration, and availability. This page shows live pricing from 25+ providers updated every 60 seconds. Scroll to the Live Cloud Pricing section to compare current rates.
How much VRAM does the MI250X have compared to the MI300X?▾
The MI250X has 128 GB of HBM2e memory. The MI300X has 192 GB of HBM3 memory.
Can I find MI250X and MI300X GPUs available to rent right now?▾
Yes. This page shows real-time availability across 25+ cloud GPU providers. The Live Cloud Pricing section displays only in-stock offers with current pricing.
What is the main difference between the MI250X and the MI300X?▾
The MI250X uses the CDNA 2 architecture (2021) while the MI300X uses CDNA 3 (2023). The MI300X delivers 3.4x the FP16 throughput and 1.6x the memory bandwidth of the MI250X.